Other names：Arg3.1; Activity-regulated gene 3.1 protein homolog
Function: Master regulator of synaptic plasticity that
self-assembles into virion-like capsids that encapsulate RNAs and
mediate intercellular RNA transfer in the nervous system. ARC
protein is released from neurons in extracellular vesicles that
mediate the transfer of ARC mRNA into new target cells, where ARC
mRNA can undergo activity-dependent translation.
ARC capsids are endocytosed and are able to transfer ARC mRNA into
the cytoplasm of neurons. Acts as a key regulator of synaptic
plasticity: required for protein synthesis-dependent forms of
long-term potentiation (LTP) and depression (LTD) and for the
formation of long-term memory.
50 MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL100
AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE150
TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV200
GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG250
EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA300
KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ350
FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ390
RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE
The kit is a sandwich enzyme immunoassay for the in vitro
quantitative measurement of ARC in human tissue homogenates, cell
lysates or other biological fluids.
78.125-5000pg/mL. The standard curve concentrations used for the
ELISA’s were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312pg/mL,
The minimum detectable dose of ARC is typically less than 31pg/mL.
The sensitivity of this assay, or Lower Limit of Detection (LLD)
was defined as the lowest protein concentration that could be
differentiated from zero. It was determined by adding two standard
deviations to the mean optical density value of twenty zero
standard replicates and calculating the corresponding
This assay has high sensitivity and excellent specificity for
detection of ARC.
No significant cross-reactivity or interference between ARC and
analogues was observed.You can reference link of the kit as following